What was the primary challenge faced by Nicholas Biddle as president of the Second Bank of the United States?

Nicholas Biddle's primary challenge as president of the Second Bank of the United States was political opposition from President Andrew Jackson. Jackson vehemently opposed the Bank, viewing it as a symbol of elite power and a threat to the democratic principles he championed. He believed that the Bank concentrated too much economic power in the hands of a privileged few and was detrimental to the common people.

Biddle faced great difficulties in trying to maintain the Bank's status and influence amidst Jackson's campaign to dismantle it. Jackson's successful move to withdraw federal funds from the Bank and ultimately veto the recharter of the Bank in 1832 significantly weakened Biddle's position and highlighted the contentious relationship between the executive branch and the institution. This political battle crystallized into a broader conflict over banking, economic power, and the role of the federal government in American life, making Jackson's opposition a central and defining obstacle for Biddle during his tenure.