Which event involved the forced relocation of the Cherokee people resulting in significant loss of life?

The Trail of Tears refers to the forced relocation of the Cherokee Nation and other Native American tribes from their ancestral homelands in the Southeastern United States to designated "Indian Territory" in present-day Oklahoma. This event occurred during the 1830s and was a direct result of the Indian Removal Act of 1830, which authorized the federal government to negotiate treaties that would require Native Americans to relinquish their land. The journey was marked by extreme hardship, including exposure to harsh weather, inadequate supplies, and disease, leading to significant loss of life among the Cherokee and other tribes involved. Ultimately, the Trail of Tears serves as a profound example of the consequences of U.S. policies toward Native Americans during the period of westward expansion.